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Research in our laboratory is aimed at understanding endocrine control of physiological processes in fish, and applying endocrinology to aquaculture and fisheries enhancement. Specific projects focus on growth and development. A broad range of experimental approaches to the problems are involved, from hormonal dietary treatment of hundreds of thousands of fish to studies of the molecular mechanisms of hormonal control of gene expression and biochemical purification of hormones. Studies currently in progress include (1) roles of pituitary gonadotropic hormones in control of salmon maturation; (2) hormonal control of the parr-smolt transformation of salmon and associated phenomena of seawater tolerance and downstream migration; (3) purification of hormones and development of new assays for hormones in blood; (4) characterization and measurement of hormone receptors in fish tissues; (5) embryonic and larval development of endocrine organs; and (6) the respective roles of growth hormone, insulin and growth factors in regulation of fish growth and metabolism.